Wednesday, January 1, 2014

Improve Memory With Phosphatidylserine & DHA

Phosphatidylserine is a naturally occurring phospholipid found in both plants and animals and can drastically improve memory function when added to a daily regimen of DHA Omega-3 fatty acids. Only 500mg Phosphatidylserine taken orally every day can improve neurotransmitter functioning between synapses of the brain and has been shown to significantly improve memory and cognitive functioning.  One study conducted by Dr. Satoru Suzuki and colleagues at the Yakult Central Institute for Microbiological Research, showed that phosphatidylserine aided in the improvement of memory in aging rats which drastically improved their ability to navigate through a water maze escape test.  Other testing in vivo (on mice and rats) proved to be successful when enhancing their memory and cognitive functioning against age-related oxidation and density loss.
Moreover, when phosphatidylserine is paired with DHA Omega-3 fatty acids, short-term and long-term memory retention and focusing ability are improved, as well as an increased brain (more exact, the hippocampus and amygdala) phospholipid retention. This phospholipid retention in the hippocampus allows for better computation, comprehension and recalling of both short-term and long-term memories.  The hippocampus is also responsible for spatial navigation, which also shows improvement when phosphatidylserine and DHA are consumed. The amygdala is not only responsible for sensory reception and projection, but it also controls memory organization and storage of emotions; phospholipid retention enhances its ability to function properly.

Because phosphatidylserine and DHA work so well hand-in-hand in improving memory and spatial navigation, a wide range of people can benefit from the combination: 
  • Children or adults with learning disabilities
  • Competitive athletes
  • College students
  • Children with poor dietary habits
  • People who have suffered from a brain injury
  • People in high-stress occupations
  • People showing signs of age-related memory loss
  • People with a genetic predisposition to dementia

The correct dosage of phosphatidylserine and DHA varies with age, weight, diet, and specific needs.  While a grown, healthy male may need 500mg of phosphatidylserine and 2,500 mg of DHA per day, a child may only need half that amount.  While there are no known side effects or toxicity levels of phosphatidylserine, the sources from which it is derived should be considered.  DHA Omega-3 fatty acids should be derived from cold-water sources.         

Enzymotec Ltd. (2010)  Sub-Chronic Toxicity Evaluation of Phosphatidylserine in Elderly Rat Model. Enzymotec Delivering Lipids. Retrieved from

Petursdottir, A., et al (2008) Effect of Dietary n-3 Polyunsaturated Fatty Acids on Brain Lipid Fatty Acid Composition, Learning Ability, and Memory of Senescene-Accelerated Mouse. The Journals of Gerontology. Retrieved from
Suzuki, S., et al. (2001) Oral Administration of Soybean Lecithin Transphosphatidylated Phosphatidylserine Improves Memory Impairment in Aged Rats. The American Society for Nutritional Sciences. Retrieved from

Thorne Research, Inc. (2008) Phosphatidylserine. Alternative Medicine Review. Retrieved from

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